Speciosa Bali Kratom
04 Mar 2011
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Speciosa Bali Kratom
Self-treatment of opioid withdrawal using kratom
This is an article describing how Kratom can be beneficial for opiate withdrawal. Users must utilize Kratom that is High Quality such as Maeng Da Kratom Powder and/or Bali Kratom Powder from places such as www.kratomquality.com
Kratom products are not FDA-approved, and it for external use only as an exotic incense. Not for human consumption.
Self-treatment of opioid withdrawal using kratom
(Mitragynia speciosa korth)
Edward W. Boyer1, Kavita M. Babu1, Jessica E. Adkins2, Christopher R. McCurdy2,3 &
John H. Halpern
Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School,Worcester, MA, USA,1 Departments of Medicinal Chemistry2and Pharmacology,3School of Pharmacy, University of Mississippi, Oxford, MS, USA and Biological Psychiatry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA4
ABSTRACT
Background
Kratom (Mitragynia speciosa korth) is recognized increasingly as a remedy for opioid withdrawal by
individuals who self-treat chronic pain.Case description A patient who had abruptly ceased injection hydromor- phone abuse self-managed opioid withdrawal and chronic pain using kratom. After co-administering the herb with modafinil he experienced a tonic-clonic seizure, but he reported only modest abstinence once kratom administration stopped. We confirmed the identity of the plant matter he ingested as kratom and identified no contaminants or adulterants. We also conducted high-throughput molecular screening and the binding affinity at mu, delta and kappa receptors of mitragynine.Conclusion We report the self-treatment of chronic pain and opioid withdrawal with kratom. The predominant alkaloid of kratom, mitragynine, binds mu- and kappa-opioid receptors, but has additional receptor affinities that might augment its effectiveness at mitigating opioid withdrawal. The natural history of kratom use, including its clinical pharmacology and toxicology, are poorly understood.
Keywords: Dependence, kratom, molecular screening, opioid, opioid replacement, withdrawal
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